K-RITH and Africa Centre have joined to form a new interdisciplinary institute, called the Africa Health Research Institute. Click here to read more.

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K-Rith

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K-RITH conducts cutting-edge scientific research on TB and HIV and aims to translate the findings into new tools to control these diseases.

Research

In late stage infection TB becomes a macrophage ‘serial killer’

Using cutting edge technologies, Africa Health Research Institute (AHRI) scientists have discovered the mechanism which Mycobacterium tuberculosis (M.tb) uses to break down host defences in late stage infection. In a paper published in eLife, researchers for the first time show how M.tb turns lung granulomas, usually tasked with controlling TB infection, against the body. Mycobacterium

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General

Qualitative Interviewer Training Programme opportunities

The Africa Health Research Institute (AHRI) is seeking highly motivated and outstanding individuals, with a strong interest in qualitative research, to join our two-week long Qualitative Interviewer Training Programme. Preference will be given to candidates who are resident and a member of a homestead from within our Population Intervention Platform Study Area (PIPSA) whose boundaries

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Our Scientists

Adrie Steyn

STEYN LAB

The main goal of the Steyn Lab’s research is to understand the mechanisms whereby Mycobacterium tuberculosis persist for decades without causing disease, to then suddenly explode.

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Al Leslie

LESLIE LAB

The Leslie Lab investigates the innate immune response to HIV and TB and how novel aspects of this response may potentially be exploited to improve patient outcomes.

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Alex Sigal

SIGAL LAB

The aim of the Sigal Lab is to understand HIV and TB transmission between cells and how it affects the persistence of infection, sensitivity to drugs, rate of the infection cycle and, for HIV, the formation of a quasispecies.

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Alexander Pym

PYM LAB

The Pym Lab focusses on understanding how the TB bacterium is able to tolerate or resist antibiotics.

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Frederick Balagaddé

BALAGADDE LAB

The Balagaddé lab hosts the first microfluidic chip-making foundry in Africa. They are developing medical microchip systems to help control the HIV and TB co-epidemic in South Africa and beyond.

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Thumbi Ndung'u

NDUNG'U LAB

The goal of the Ndung’u laboratory is to understand immune mechanisms against HIV and tuberculosis, and pathogen evasion of immune responses as a pathway to vaccine development.

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NEWS | Research

In late stage infection TB becomes a macrophage ‘serial killer’

Using cutting edge technologies, Africa Health Research Institute (AHRI) scientists have discovered the mechanism which Mycobacterium tuberculosis (M.tb) uses to break down host defences in late stage infection. In a paper published in eLife, researchers for the first time show how M.tb turns lung granulomas, usually tasked with controlling TB infection, against the body. Mycobacterium

READ MORE
NEWS | General

Qualitative Interviewer Training Programme opportunities

The Africa Health Research Institute (AHRI) is seeking highly motivated and outstanding individuals, with a strong interest in qualitative research, to join our two-week long Qualitative Interviewer Training Programme. Preference will be given to candidates who are resident and a member of a homestead from within our Population Intervention Platform Study Area (PIPSA) whose boundaries

READ MORE
NEWS | Research

Linking HIV positive people to care in rural KZN remains a challenge

New research published in the Lancet HIV shows that linking HIV infected people to clinical care and treatment is a critical gap in the South African Health Department’s HIV treatment programme in rural KwaZulu-Natal. The research utilises one of the most comprehensive clinical and population surveillance databases in the world in order to quantify each

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