Scientific Challenges

Estimated incidence per 100,000 population (2008)
Source: World Health Organization
Confirmed multi-drug resistant TB cases (2008)
Source: World Health Organization
Estimated incidence (2007)
Source: World Health Organization
Estimated TB cases who are HIV-positive(2008)
Source: World Health Organization
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Using the tools of basic science, the KwaZulu-Natal Research Institute for Tuberculosis and HIV seeks new approaches to fighting these deadly diseases.

Scientific Opportunities

K-RITH offers exciting and cutting-edge Masters, PhD and Post-doctoral research programmes aimed at developing the future leaders of science in South Africa.


Access scientific literature on HIV and TB - a resource designed to serve the HIV and TB research community at the University of KwaZulu-Natal.



Bedaquiline in the treatment of multidrug- and extensively drug-resistant tuberculosis. - European Respiratory Journal, 47(2), 564-574. doi:10.1183/13993003.00724-2015
Host-Directed Therapies for Tackling Multi-Drug Resistant Tuberculosis: Learning From the Pasteur-Bechamp Debates. - Clin Infect Dis. 2015 Nov 1;61(9):1432-8. doi: 10.1093/cid/civ631. Epub 2015 Jul 28.
The effect of SLCO1B1 polymorphisms on the pharmacokinetics of rifabutin in African HIV-infected patients with tuberculosis. - Antimicrob Agents Chemother. 2015 Oct 19. pii: AAC.01195-15. [Epub ahead of print]
Metabolic plasticity of central carbon metabolism protects mycobacteria. - Proc Natl Acad Sci U S A. 2015 Oct 27;112(43):13135-6. doi: 10.1073/pnas.1518171112. Epub 2015 Oct 19.
Regulation of Ergothioneine Biosynthesis and Its Effect on Mycobacterium tuberculosis Growth and Infectivity. - J Biol Chem. 2015 Sep 18;290(38):23064-76. doi: 10.1074/jbc.M115.648642. Epub 2015 Jul 30.
Magnitude and Kinetics of CD8+ T Cell Activation during Hyperacute HIV Infection Impact Viral Set Point. - Immunity. 2015 Sep 15;43(3):591-604. doi: 10.1016/j.immuni.2015.08.012. Epub 2015 Sep 8.
HIV Disrupts Human T Cells That Target Mycobacterial Glycolipids. - J Infect Dis. 2015 Sep 15. pii: jiv455. [Epub ahead of print]
Epigenetic mechanisms, T-cell activation, and CCR5 genetics interact to regulate T-cell expression of CCR5, the major HIV-1 coreceptor. - Proc Natl Acad Sci U S A. 2015 Aug 25;112(34):E4762-71. doi: 10.1073/pnas.1423228112. Epub 2015 Aug 11.
Evidence for the presence of clofazimine and its distribution in the healthy mouse brain. - J Mol Histol. 2015 Oct;46(4-5):439-42. doi: 10.1007/s10735-015-9634-3. Epub 2015 Jul 25.
Towards host-directed therapies for tuberculosis - Nat Rev Drug Discov. 2015 Aug;14(8):511-2. doi: 10.1038/nrd4696. Epub 2015 Jul 17.
Psychological distress and its relationship with non-adherence to TB treatment: a multicentre study. - BMC Infect Dis. 2015 Jul 1;15:253. doi: 10.1186/s12879-015-0964-2.
Fatal nosocomial MDR TB identified through routine genetic analysis and whole-genome sequencing. - Emerg Infect Dis. 2015 Jun;21(6):1082-4. doi: 10.3201/eid2106.141903.
Viral immunology. Comprehensive serological profiling of human populations using a synthetic human virome. - Science. 2015 Jun 5;348(6239):aaa0698. doi: 10.1126/science.aaa0698.
Antibiotics. Targeting DnaN for tuberculosis therapy using novel griselimycins. - Science. 2015 Jun 5;348(6239):1106-12. doi: 10.1126/science.aaa4690.
Efficacy of Rifampin Plus Clofazimine in a Murine Model of Mycobacterium ulcerans Disease. - PLoS Negl Trop Dis. 2015 Jun 4;9(6):e0003823. doi: 10.1371/journal.pntd.0003823. eCollection 2015.
Biomarkers for tuberculosis based on secreted, species-specific, bacterial small molecules - Journal of Infectious Diseases 2015 May 26. pii: jiv312. [Epub ahead of print]
CD8+ T-cell receptor bias and immunodominance in HIV-1 infection - Journal of Immunology. 2015 Apr 24. pii: 1400854. [Epub ahead of print]. PMID: 25911754.
In vivo biosynthesis of terpene nucleosides provides unique chemical markers of Mycobacterium tuberculosis infection. - Chem Biol. 2015 Apr 23;22(4):516-26. doi: 10.1016/j.chembiol.2015.03.015.
Knowledge of HIV Serodiscordance, Transmission, and Prevention among Couples in Durban, South Africa - PLoS One 2015 Apr 20;10(4):e0124548. doi: 10.1371/journal.pone.0124548. eCollection 2015. PMID: 25894583.
Pharmacokinetics and pharmacodynamics of clofazimine in a mouse model of tuberculosis. - Antimicrob Agents Chemother. 2015;59(6):3042-51. doi: 10.1128/AAC.00260-15. Epub 2015 Mar 9.
High Expression of CD26 Accurately Identifies Human Bacterial-Reactive MR1-restricted MAIT cells - Immunology 2015 Mar 5. doi: 10.1111/imm.12461. [Epub ahead of print]. PMID: 25752900
Comparative Genomics of Cluster O Mycobacteriophages - PLoS One. 2015 Mar 5;10(3):e0118725
Effective anti-tuberculosis therapy correlates with plasma small RNA. - Eur Respir J. 2015 Jun;45(6):1741-4. doi: 10.1183/09031936.00221214. Epub 2015 Mar 5.
Characterization of mouse models of Mycobacterium avium complex infection and evaluation of drug combinations. - Antimicrob Agents Chemother. 2015 Apr;59(4):2129-35. doi: 10.1128/AAC.04841-14. Epub 2015 Jan 26.
HIV-1 vaccine immunogen design strategies - Virology Journal 2015 Jan 24;12(1):3. [Epub ahead of print]
Clofazimine shortens the duration of the first-line treatment regimen for experimental chemotherapy of tuberculosis. - Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):869-74. doi: 10.1073/pnas.1416951112. Epub 2015 Jan 5.
Global biogeographic sampling of bacterial secondary metabolism - eLife. 2015; 4: e05048. Published online 2015 Jan 19. doi: 10.7554/eLife.05048
Impact of HLA-driven HIV adaptation on virulence in populations of high HIV seroprevalence - Proceedings of the National Academy of Sciences USA 2014 Dec 16;111(50):E5393-400
Rapid sequencing of the Mycobacterium tuberculosis pncA gene for the detection of pyrazinamide susceptibility. - J Clin Microbiol. 2014 Aug 27. pii: JCM.02438-14. [Epub ahead of print]
Multidrug-resistant tuberculosis and culture conversion with bedaquiline. - N Engl J Med. 2014 Aug 21;371(8):723-32. doi: 10.1056/NEJMoa1313865.
Completeness and Reliability of the Republic of South Africa National Tuberculosis (TB) Surveillance System. - BMC Public Health. 2015 Aug 11;15(1):765. doi: 10.1186/s12889-015-2117-3.
The fitness landscape of HIV-1 gag: advanced modeling approaches and validation of model predictions by in vitro testing. - PLoS Comput Biol. 2014 Aug 7;10(8):e1003776. doi: 10.1371/journal.pcbi.1003776. eCollection 2014.
Comparison of Amplicor and GeneXpert MTB/RIF Tests for Diagnosis of Tuberculous Meningitis. - J Clin Microbiol. 2014 Oct;52(10):3777-80. doi: 10.1128/JCM.01235-14. Epub 2014 Jul 23.
Biological differences between the sexes and susceptibility to tuberculosis. - J Infect Dis. 2014 Jul 15;209 Suppl 3:S100-6. doi: 10.1093/infdis/jiu147.
HIV transmission. Selection bias at the heterosexual HIV-1 transmission bottleneck - Science. 2014 Jul 11;345(6193):1254031. doi: 10.1126/science.1254031. Epub 2014 Jul 10.
Selection of RNA aptamers against the M. tuberculosis EsxG protein using surface plasmon resonance-based SELEX. - Biochem Biophys Res Commun. 2014 Jun 20;449(1):114-9. doi: 10.1016/j.bbrc.2014.04.163. Epub 2014 May 9.
RNA and imidazoquinolines are sensed by distinct TLR7/8 ectodomain sites resulting in functionally disparate signaling events. - J Immunol. 2014 Jun 15;192(12):5963-73. doi: 10.4049/jimmunol.1303058. Epub 2014 May 9.
Effect of Female Genital Schistosomiasis and Anti-Schistosomal Treatment on Monocytes, CD4+ T-Cells and CCR5 in the Female Genital Tract. - PLoS One 2014 Jun 4;9(6):e98593. doi: 10.1371/journal.pone.0098593. eCollection 2014. PMID 24896815.
Consensus standards for introductory e-learning courses in human participants research ethics. - J Med Ethics. 2014 Jun;40(6):426-8. doi: 10.1136/medethics-2013-101572. Epub 2013 Aug 19.
HIV Subtype Influences HLA-B*07:02-Associated HIV Disease Outcome. - AIDS Res Hum Retroviruses. 2014 May;30(5):468-75. doi: 10.1089/AID.2013.0197. Epub 2013 Oct 4.
TRIM5α and TRIM22 are differentially regulated according to HIV-1 infection phase and compartment. - J Virol. 2014 Apr;88(8):4291-303. doi: 10.1128/JVI.03603-13. Epub 2014 Jan 29.
Regulatory T cells expanded from HIV-1-infected individuals maintain phenotype, TCR repertoire and suppressive capacity. - PLoS One. 2014 Feb 3;9(2):e86920. doi: 10.1371/journal.pone.0086920. eCollection 2014.
Neutrophil counts in persons of African origin. - Curr Opin Hematol. 2014 Jan;21(1):50-7. doi: 10.1097/MOH.0000000000000007.
Low levels of peripheral CD161++CD8+ Mucosal Associated Invariant T (MAIT) cells are found in HIV and HIV/TB co-infection - PLos ONE, 2013 Dec 31; 8(12):e83474. Doi: 10.1371/journal.pone.0083474. (PMID: 234391773)
Whole-genome sequencing to establish relapse or re-infection with Mycobacterium tuberculosis: a retrospective observational study. - Lancet Respir Med. 2013 Dec;1(10):786-92. doi: 10.1016/S2213-2600(13)70231-5. Epub 2013 Nov 21.
High-throughput sequencing enhanced phage display identifies peptides that bind mycobacteria. - PLoS One. 2013 Nov 12;8(11):e77844. doi: 10.1371/journal.pone.0077844. eCollection 2013.
S100A8/A9 proteins mediate neutrophilic inflammation and lung pathology during tuberculosis. - Am J Respir Crit Care Med. 2013 Nov 1;188(9):1137-46. doi: 10.1164/rccm.201304-0803OC.
Diagnostic accuracy of quantitative PCR (Xpert MTB/RIF) for tuberculous meningitis in a high burden setting: a prospective study. - PLoS Med. 2013 Oct;10(10):e1001536. doi: 10.1371/journal.pmed.1001536. Epub 2013 Oct 22
The intracellular sensor NOD2 induces microRNA-29 expression in human dendritic cells to limit IL-23 release. - Immunity. 2013 Sep 19;39(3):521-36. doi: 10.1016/j.immuni.2013.08.035.
Ability of HIV-1 Nef to downregulate CD4 and HLA class I differs among viral subtypes. - Retrovirology. 2013 Sep 16;10:100. doi: 10.1186/1742-4690-10-100.
Nef-specific CD8+ T cell responses contribute to HIV-1 immune control. - PLoS One. 2013 Sep 2;8(9):e73117. doi: 10.1371/journal.pone.0073117. eCollection 2013
Nef-specific CD8+ T cell responses contribute to HIV-1 immune control. - PLoS One. 2013 Sep 2;8(9):e73117. doi: 10.1371/journal.pone.0073117. eCollection 2013.
Clinical and mycological predictors of cryptococcosis-associated immune reconstitution inflammatory syndrome. - AIDS. 2013 Aug 24;27(13):2089-99. doi: 10.1097/QAD.0b013e3283614a8d.
Immunohistological characterization of spinal TB granulomas from HIV-negative and -positive patients. - Tuberculosis (Edinb). 2013 Jul;93(4):432-41. doi: 10.1016/ Epub 2013 Mar 28.
Structure and interactions of the human programmed cell death 1 receptor. - J Biol Chem. 2013 Apr 26;288(17):11771-85. doi: 10.1074/jbc.M112.448126. Epub 2013 Feb 15.
EDCTP regional networks of excellence: initial merits for planned clinical trials in Africa. - BMC Public Health. 2013 Mar 22;13:258. doi: 10.1186/1471-2458-13-258.
Changes in Natural Killer cell activation and function during primary HIV-1 Infection. - PLoS One. 2013;8(1):e53251. doi: 10.1371/journal.pone.0053251. Epub 2013 Jan 9.
The Physiology and genetics of oxidative stress in mycobacteria - In: Molecular Genetics of Mycobacteria. 2nd edition 2013
Characterization of anti-HIV-1 neutralizing and binding antibodies in chronic HIV-1 subtype C infection. - Virology. 2012 Nov 25;433(2):410-20. doi: 10.1016/j.virol.2012.08.033. Epub 2012 Sep 18.
Co-operative additive effects between HLA alleles in control of HIV-1. - PLoS One. 2012;7(10):e47799. doi: 10.1371/journal.pone.0047799. Epub 2012 Oct 19.
Heme oxygenase-1 promotes granuloma development and protects against dissemination of mycobacteria. - Lab Invest. 2012 Nov;92(11):1541-52. doi: 10.1038/labinvest.2012.125. Epub 2012 Sep 10.
Modeling early bactericidal activity in murine tuberculosis provides insights into the activity of isoniazid and pyrazinamide. - Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):15001-5. doi: 10.1073/pnas.1203636109. Epub 2012 Aug 27.
As Good As It Gets? The Problem of HIV Persistence despite Antiretroviral Drugs. - Cell Host Microbe. 2012 Aug 16;12(2):132-8. *Corresponding author.
Mycobacterium tuberculosis WhiB4 regulates oxidative stress response to modulate survival and dissemination in vivo. - Mol Microbiol. 2012 Sep;85(6):1148-65. doi: 10.1111/j.1365-2958.2012.08165.x. Epub 2012 Jul 26.
Environmental heme-based sensor proteins: implications for understanding bacterial pathogenesis. - Antioxid Redox Signal. 2012 Nov 1;17(9):1232-45. doi: 10.1089/ars.2012.4613. Epub 2012 Jun 13.
Iron sulfur cluster proteins and microbial regulation: implications for understanding tuberculosis. - Curr Opin Chem Biol. 2012 Apr;16(1-2):45-53. doi: 10.1016/j.cbpa.2012.03.004. Epub 2012 Apr 4.
Mycobacterium tuberculosis WhiB3: a novel iron-sulfur cluster protein that regulates redox homeostasis and virulence. - Antioxid Redox Signal. 2012 Apr 1;16(7):687-97. doi: 10.1089/ars.2011.4341.
Reduced antituberculosis drug concentrations in HIV-infected patients who are men or have low weight: implications for international dosing guidelines. - Antimicrob Agents Chemother. 2012 Jun;56(6):3232-8. doi: 10.1128/AAC.05526-11. Epub 2012 Mar 12.
Human MAIT and CD8αα cells develop from a pool of type-17 precommitted CD8+ T cells. - Blood. 2012 Jan 12;119(2):422-33. doi: 10.1182/blood-2011-05-353789. Epub 2011 Nov 15.
Redox homeostasis in mycobacteria: the key to tuberculosis control? - Expert Rev Mol Med. 2011 Dec 16;13:e39. doi: 10.1017/S1462399411002079.
International Spread of MDR TB from Tugela Ferry, South Africa - Emerg Infect Dis. 2011 Nov;17(11):2035-7. doi: 10.3201/eid1711.110291.
In silico children and the glass mouse model - Antimicrob Agents Chemother. 2011 Feb
The new role of the microchemostat in the bioengineering revolution - 31st Annual International Conference of the IEEE Engineering in Medicine and Biology Society
Intersubtype differences in the effect of a rare p24 gag mutation on HIV-1 replicative fitness. - J Virol. 2012 Dec;86(24):13423-33. doi: 10.1128/JVI.02171-12. Epub 2012 Sep 26.
HIV control through a single nucleotide on the HLA-B locus. - J Virol. 2012 Nov;86(21):11493-500. doi: 10.1128/JVI.01020-12. Epub 2012 Aug 15.
August 10, 2016

Research by K-RITH scientists has opened up possibilities for the development of new, better and faster ways to treat tuberculosis (TB).

July 29, 2016

K-RITH’s Dr Henrik Kløverpris has been awarded a prestigious five-year Sir Henry Dale Fellowshipto support his research into the immune system’s response to HIV infection.

July 26, 2016

K-RITH Investigator Dr Alex Pym speaks to Science Magazine’s Jon Cohen about his lab’s work on drug resistant TB.

July 18, 2016

K-RITH and the Africa Centre for Population Health are joining to form an exciting new interdisciplinary research institute, called the Africa Health Research Institute. We aim to become a source of fundamental discoveries into the susceptibility, transmission and cure of HIV and TB and related diseases, seeking always to improve diagnosis, prevention and treatment.

June 8, 2016

Dr Frederick Balagaddé is looking for a highly motivated, self-directed candidate to join his lab as a Postdoctoral Research Fellow.

July 29, 2016

Dr Darshan Reddy, Consultant Cardiothoracic Surgeon at Inkosi Albert Luthuli Central Hospital, and Professor Adrie Steyn, K-RITH Investigator, will be presenting a talk at K-RITH on Friday, July 29.

July 4, 2016 - July 15, 2016

Discover new bacteriophages that may contribute towards the treatment of tuberculosis!

May 16, 2016

Associate Professor Anette Stryhn, from the Department of Immunology and Microbiology at the University of Copenhagen, will be presenting a talk at K-RITH on Monday, 16 May.

May 16, 2016

Professor Søren Buus from the Laboratory of Experimental Immunology, University of Copenhagen, will be presenting a talk at K-RITH on Monday, May 16.

April 7, 2016
Dr Jeffrey Dorfman, Group Leader of the Cellular Immunology Lab at the International Centre for Genetic Engineering and Biotechnology, and Honorary Senior Lecturer at UCT, will be presenting a talk at K-RITH on Thursday, 7 April, as part of our Seminar Series.